Rheumatology And IMMUNOLOGY Notes [PDF] By Dr. Srinath.Chandramani

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Summary oF the Book::

INTRODUCTION TO IMMUNE SYSTEM
• Immunity is broadly divided into :
– Innate immunity
– Adaptive immunity
• Individual constituents are the MonocyteMacrophage system, Dendritic cells, NK cells and the
Granulocytes (N, E and Basophils)
• T-Cells and B-cells respectively.

Other Mediators of immunity are :
– Immunoglobulins
– Interferons
– Complement cascade

Deficiencies of the Innate Immune SystemPhagocytic cells:
– Impaired production: severe congenital neutropenia (SCN)
– Asplenia
– Impaired adhesion: leukocyte adhesion deficiency (LAD)
– Impaired killing: chronic granulomatous disease (CGD)
Innate immunity receptors and signal transduction:
– Defects in Toll-like receptor signaling
– Mendelian susceptibility to mycobacterial disease
Complement deficiencies:
– Classical, alternative, and lectin pathways
– Lytic phase

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