The Use of Hyaluronidase in Cosmetic Dermatology [PDF] 
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Abstract
Background: Hyaluronidase can be employed to manage a variety of complications associated with cosmetic hyaluronic acid (HA) fller injection. However, the indications and treatment protocol for hyaluronidase use have not been well established.
Objective: Review of the available literature to describe the use of
hyaluronidase in the reversal of HA fller injection.
Methods: PubMed/MEDLINE databases were utilized to identify case
reports and studies pertaining to the use of hyaluronidase after HA
fller injection.
Results: Hyaluronidase can be successfully employed in the
management of uncomplicated nodules and overcorrection,
inflamed nodules, or tissue ischemia associated with HA fller injection.
Hyaluronidase use is dependent on the clinical indication, anatomical
location, and original injected HA quantity.
Conclusion: Hyaluronidase is an important tool for clinicians utilizing
cosmetic HA fller injection. Further reports and studies are warranted
to frmly establish the ideal treatment protocol.